Biological link between high blood sugar and Alzheimer’s disease identified

Research published in the journal Scientific Reports sheds new light on the biological links between dementia and high blood sugar, a common symptom of diabetes.

Researchers at University of Bath compared brain samples of 30 people with and without Alzheimer’s disease and tested them for protein glycation, a modification caused by high glucose levels in the blood.



The team found that a particular enzyme was glycated in the brains of people with Alzheimer’s disease and that glycation stopped the enzyme from working properly. The enzyme, known as ‘macrophage migration inhibitory factor’ or MIF, has been previously implicated in the inflammatory response that occurs in the brains of people with Alzheimer’s disease.


Read the full article in Scientific Reports here